The oncogenic effect of miRNA-21 in human glioma cells is implemented through the suppression of such tumor suppressor genes as TAp63, HNRPK, JMY, TOPORS, RECK, TP53BP2, TIMP3, PDCD4, and TGFBR2/3 [19]. The gene discussed is TP53BP2; the disease is central nervous system cancer.