Patients diagnosed with COVID-19 had an extreme amount of mRNA generation and production of the cytokines IL-1β, IL-6, TNF-α, and IL-18; however, patients treated with nano curcumin exhibited a substantial decline in IL-6 and IL-1β levels (Valizadeh et al., 2020; Tahmasebi et al., 2021). The gene discussed is IL1B; the disease is COVID-19.