Previously, curcumin was able to reduce the parasitemia in T. cruzi infected animals (Nagajyothi et al., 2013) which is explained by the inhibitory effect of curcumin at the transcription of low-density lipoprotein receptor (LDLr) (Yuan et al., 2008; Kang and Chen, 2009; Nagajyothi et al., 2013) as it is known that the T. cruzi utilizes these LDLr during its cellular invasion process (Nagajyothi et al., 2011). This evidence concerns the gene LDLR and parasitic infectious disease.