SLC2A1 and Alzheimer disease: Aβ deposition is linked to a reduction in glucose transporter type-1 (GLUT-1) levels in AD mouse brains (Hooijmans et al. 2007) and Aβ decreased glucose transport in cortical and hippocampal neurons by the formation of 4-hydroxynonenal, a product of lipid peroxidation (Mark et al. 1997).