AQP1 and colorectal cancer: On the other hand, oncogenes experienced a hypomethylation status as a mechanism for their activation to induce tumor progression (Romero-Garcia et al., 2020); for example, a hypomethylation state was reported for the oncogenes AQP1, LINE-1, and ELMO3 in salivary gland adenoid cystic carcinoma (Shao et al., 2011), colorectal cancer (Hur et al., 2014), and lung cancer (Søes et al., 2014) respectively.