MDM2 and ovarian carcinoma: Studying the oncogenic role of CHD1L showed that it can upregulate two genes, mouse double minute two homolog (MDM2) and methionyl aminopeptidase 2 (METAP2), where the first one was associated with breast cancer progression (Wang et al., 2019) and the later was linked to epithelial ovarian cancer metastasis and invasiveness (He et al., 2020).