Studying the oncogenic role of CHD1L showed that it can upregulate two genes, mouse double minute two homolog (MDM2) and methionyl aminopeptidase 2 (METAP2), where the first one was associated with breast cancer progression (Wang et al., 2019) and the later was linked to epithelial ovarian cancer metastasis and invasiveness (He et al., 2020). This evidence concerns the gene CHD1L and breast cancer.