On the other hand, oncogenes experienced a hypomethylation status as a mechanism for their activation to induce tumor progression (Romero-Garcia et al., 2020); for example, a hypomethylation state was reported for the oncogenes AQP1, LINE-1, and ELMO3 in salivary gland adenoid cystic carcinoma (Shao et al., 2011), colorectal cancer (Hur et al., 2014), and lung cancer (Søes et al., 2014) respectively. Here, ELMO3 is linked to colorectal cancer.