Consistently, ERS inhibition provides effective protection against various diseases, such as rescuing neuronal death in ischemia brain, promoting insulin sensitivity in adipose tissue, and reducing myocardial cell apoptosis in diabetic cardiomyopathy by alleviating cell damage and improving ER function (Zhang et al., 2014; Guo et al., 2017; Idari et al., 2021). This evidence concerns the gene INS and ischemia.