NUP98 and early-onset autosomal dominant Alzheimer disease: One of the essential proteins forming the barrier is Nup98.3 It has been shown that Nup98 interacts with tau and is mislocalized into the cytoplasm in Alzheimer’s disease.4 In their recent article in Brain Communications, Dickson et al. reported that Nup98 is mislocalized in the frontal cortex of several primary tauopathies like FTLD-tau, CBD and PSP.5 The data indicate that Nup98 mislocalization is a general feature of primary tauopathies and is associated with pathological tau accumulation and neurotoxicity (Fig. 1).