NUP62 and early-onset autosomal dominant Alzheimer disease: Nup62, a crucial component of the NPC permeability barrier, has been found to be involved in several neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease and ALS/FTLD.8,9 In ALS/FTLD, the Nup62 form condensates with the protein TDP-43.