The disruption of the NCT in neurons is a phenomenon that has also been observed in many other neurodegenerative diseases like Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis (ALS), etc. Other proteins involved in NCT, like the FG-Nup Nup62, and nuclear transport receptors (NTRs), like importin-α5 and β1, have also been found to be compromised in neurodegenerative diseases. The gene discussed is NUP62; the disease is Huntington disease.