MAPT and early-onset autosomal dominant Alzheimer disease: Though the current study does not look into the mechanism behind the Nup98 mislocalization, a direct interaction of pathological phospho-tau and Nup98 could be the cause of mislocalization of Nup98 in these tauopathies based on the fact that there exists a correlation between the number of AT8-positive neurons and neurons with abnormal nuclear and cytoplasmic localization of Nup98, combined with the evidence of interaction between Nup98 and tau in Alzheimer’s disease.7 The mislocalization of Nup98 suggests that the NCT in these tauopathies is compromised.