LAMP5 is highly and specifically expressed in mixed lineage leukemia-rearranged (MLL-r) leukemias and is associated with poor prognosis, and downregulation of LAMP5 leads to inhibition of NF-kB signaling and increased activation of type 1 interferon signaling downstream of Toll-like receptor/interleukin 1 receptor activation (17, 18). This evidence concerns the gene LAMP5 and leukemia.