The MSRPI consists of seven metabolic syndrome-related genes (MSRGs), including CSF3R, TMEM132A, STAB1, VIM, DUOXA1, PILRB, and SLC2A4. Of these MSRGs, abnormal colony-stimulating factor receptor (CSFR) expression plays an oncogenic role in many hematologic and solid tumors, such as nasopharyngeal, breast, and ovarian cancers (35–37), but its role in PCa remains unclear. Here, DUOXA1 is linked to metabolic syndrome.