Low-risk LUAD patients showed increased infiltration of various immune cells, including Active dendritic cells (aDCs), B cells, CD8+ T cells, Dendritic cells (DCs), Immature dendritic cells (iDCs), Mast cells, neutrophils, T helper cell, Tumor-infiltrating lymphocytes (TILs), and Regulatory T cells (Treg), in their tumor microenvironment (TME). The gene discussed is CD8A; the disease is neoplasm.