We used KEGG enrichment analysis to identify the relevant metabolic pathways involved in DS, and the results showed that the mammalian target of rapamycin (mTOR) signaling pathway, ABC transporters, amyotrophic lateral sclerosis, amoebiasis, pyrimidine metabolism, as well as D-arginine, and D-ornithine metabolism pathways were the primary pathways associated with DS (P < 0.05, Figure 7). Here, MTOR is linked to amyotrophic lateral sclerosis.