It has been proposed that small amounts of very low-density lipoprotein (VLDL) are synthesized and secreted by the liver in response to decreased levels of carbohydrate-responsive element-binding protein and sterol regulatory element-binding protein due to hypoglycemia, which in turn downregulates CETP expression, thereby facilitating triacylglycerols depletion from cholesteryl esters and its enrichment with HDL (46). This evidence concerns the gene MLXIPL and Hypoglycemia.