Fifteen core genes, DNAJB9, VPS53, SCGN, CMAS, RGS6, FASLG, ABHD10, ATRN, PLA2G2F, ITIH2, ROBO1, SGCG, SH3GL2, CNR1, and FOXN3, were identified as shared between NAFLD and T2D. Here, RGS6 is linked to metabolic dysfunction-associated steatotic liver disease.