Fifteen core genes, DNAJB9, VPS53, SCGN, CMAS, RGS6, FASLG, ABHD10, ATRN, PLA2G2F, ITIH2, ROBO1, SGCG, SH3GL2, CNR1, and FOXN3, were identified as shared between NAFLD and T2D. Here, VPS53 is linked to type 2 diabetes mellitus.