The association with pulse pressure and blood pressure have been associated to diabetic retinopathy through arterial stiffness and vision impairment, which has been identified in multiple genes, including the ZFHX4 gene (26, 33, 34), the SHANK3 gene (35), and the WNT9B gene (34). The gene discussed is ZFHX4; the disease is diabetic retinopathy.