The genes that contributed to the biological relevance of diabetic nephropathy, include gene TTN (rs72646845), PI16 (rs113848006), DPY6 (rs36027551), CROCC (rs41272737), PPP1R3A (rs1799999), ZNF136 (rs140861589), HSPA12B (rs6076550), and FRMD4A (rs1541010). The gene discussed is PPP1R3A; the disease is diabetic kidney disease.