NGF and neoplasm: Evidence already exists which demonstrates the potential for the role of bevacizumab in preserving and improving visual outcomes at the time of tumor progression (68); topically applied nerve growth factor has been shown to restore optic nerve function (69) in children with OPHG; preliminary research is reported where brain stem-cell therapy is being investigated for brain injury repair (70) as well as evidence of rising health service awareness of the need for early symptom awareness and specific services to support children after acquired brain injury (58, 71).