According to the results, the proportion of activated Dendritic cells, resting Dendritic cells, M0 Macrophages, M1 Macrophages, activated Mast cells, resting Mast cells, Monocytes, Neutrophils, resting NK cells, Plasma cells and memory activated CD4 T cells were higher in pediatric CD, while the proportion of memory B cells, naive B cells, M2 Macrophages, CD8 T cells, follicular helper T cells and regulatory T cells were lower (Figure 8C). Here, CD4 is linked to Cowden disease.