To investigate the biological roles of SAV1 in GC, AGS and NCI-N87 cells (which express low levels of endogenous SAV1) were transfected or infected with SAV1 expression vectors (AGS/NCI-N87-pSAV1 and AGS/NCI-N87-pBABE-SAV1). The gene discussed is SAV1; the disease is gastric cancer.