Upregulation of lipogenic enzymes and transcription factors, such as sterol regulatory element binding protein-1c (srebp-1c), the carbohydrate responsive element binding protein (ChREBP), and liver X receptor (LXR) (86), promotes de novo lipogenesis (DNL) (87), increasing the risk of lipid accumulation and obesity. This evidence concerns the gene MLXIPL and obesity due to melanocortin 4 receptor deficiency.