C5aR1+ microglia/macrophages were immunopositive for inducible nitic oxide synthase (iNOS; 6G and inset), TNFα (Figure 6H and inset), and those at or near inflammatory demyelinating lesions of the progressive MS cortex were associated with inclusions of debris-like material that stained immunopositive for PLP, non-phosphorylated neurofilament (heavy chain) and synaptophysin (Figure 6I). The gene discussed is C5AR1; the disease is myeloid sarcoma.