UCHL1 and neuroblastoma: Studies conducted on neuroblastoma SH-SY5Y and immortalized INS1 beta cells showed that silencing of UCH-L1 expression (via a shRNA strategy) induces significant changes in mitochondrial morphology and reduces interactions (tethering) between mitochondria and the ER by increasing the physical distance between the two organelles (Cerqueira et al., 2020).