However, sAβ species have been demonstrated to alter network activity before Aβ plaques are present in the brain, therefore, we hypothesized that early AD related pathological changes would interfere with hippocampal network function in the pre-plaque stage of AD (Shah et al., 2016; Ben-Nejma et al., 2019; van den Berg et al., 2022). This evidence concerns the gene SH3BP5 and Alzheimer disease.