VCAM1 and Peripheral demyelination: Furthermore, in a mouse (1-month-old) model of viral-induced demyelination, CBD (5 mg/kg; i.p) attenuated morphological alterations in microglia, and reduced production of IL-1β, chemokines, and vascular cell adhesion molecule-1 (VCAM-1) through adenosine A2A receptors (Mecha et al., 2013).