ICAM1 and fibrosis: 1. Suppressed oxidative stress by reducing the levels of superoxide, 4-hydroxynonenal and protein carbonyl 2. Decreased level of DNA damage in the myocardium 3. Ameliorated the diabetes-induced damage in heart tissues 4. Reduction in the cardiac fibrosis in cardiac tissues 5. Decreased levels of IL-1β, IL-6 and TNF-α and adhesion molecules ICAM-1 and VCAM-1 6. Reduction in the number of apoptotic and necrotic cells