Single nucleotide polymorphisms in various Met metabolic enzymes, including MS A2765G, MTRR A66G, MTHFR 677 or 1,298 gene polymorphism displayed different susceptibility to lymphoma, ALL, AML, and Chronic myeloid leukemia (CML), probably due to subtypes of malignancies, ethic factors, and gender (114–119). This evidence concerns the gene MTHFR and chronic myelogenous leukemia, BCR-ABL1 positive.