The observed correlation between AS and iron homeostasis indicators may be related by inflammation-induced upregulation of hepcidin and AS-related anemia. Inflammation affects iron homeostasis indicators by increasing hepcidin and causes AS disease aggravation. Anemia may be an intermediary factor between AS and iron homeostasis indicators. Additionally, the anemia state caused by inflammation, complications, and treatment side effects of AS may causes changes in iron homeostasis indicators. Here, HAMP is linked to anemia.