CHRNA7 and major depressive disorder: It has also been experimentally found that α7nAchR‐positive allosteric modulator can effectively prevent lipopolysaccharide‐induced anxiety, cognitive deficits, and depression‐like behaviors, and cholinergic stimulation or α7nAchR agonist injection can alleviate depression‐like behaviors in chronic restraint stress mice,32 and all of these can be prevented by α7nAchR antagonists.