Previous series of experiments also confirmed that taVNS suppresses hypothalamic inflammation and improves depression‐like behavior in animals, and it is thought to exert anti‐inflammatory effects through α7 nicotinic acetylcholine receptors (α7nAchR), for its inhibitory effect on TNF‐α can be partially eliminated by α7nAchR antagonists.15, 16. Here, CHRNA7 is linked to major depressive disorder.