INS and obesity due to melanocortin 4 receptor deficiency: Studies have demonstrated the role of hypercaloric diets in the development of experimental models of obesity due to changes in body composition, such as increased body weight (BW) and fat deposits, changes in glycemic and lipid profiles, insulin resistance, and hypertriglyceridemia (Da Silva et al., 2010; Gamelin et al., 2016; White et al., 2013).