Many ECM remodeling genes were upregulated with LAL (6 types of collagen; laminin, fibronectin, 2 types of LOXL, 3 types of MMP, TIMP3), suggesting myocardial fibrosis or fibroelastosis, which agreed with previous findings in this disease model [30, 40]. The gene discussed is TIMP3; the disease is Myocardial fibrosis.