The tumor microenvironment alterations of genetic subtypes were also strikingly discordant: the TP53Mut subtype generally presented low expression of all immune signatures, the MCD-like subtype presented low expression of T cell signatures, the EZB-like-MYC+ subtype had low expressing CD8+T cell signatures, while the EZB-like-MYC– subtype had high expressing GC TFH and CD4+T cell signatures. This evidence concerns the gene CD4 and neoplasm.