TIMP1 and Hepatic fibrosis: For example, Baicalein can regulate Nrf2/HO-1 and Bcl-2/Bax pathways to treat CCl4-induced liver fibrosis [48]; Quercetin ethyl acetate inhibits liver fibrosis in rats via decreasing the expression of α-SMA and TIMP1 depended on Nrf2 protein [49]; Ursolic acid can regulate Nrf2/ARE pathway, which can significantly prevent CCl4 induced hepatotoxicity and fibrosis [50].