Several intronic and an exonic (rs1260326P446>L) variant in the GCKR gene, within a large region of linkage disequilibrium on chromosome-2, associate with raised blood triglycerides and cholesterol and with increased risk for fatty liver disease but with decreased risk for Type 2 diabetes [[3], [4], [5], [6], [7], [8], [9]]. Here, GCKR is linked to type 2 diabetes mellitus.