For Cohort 1, CD3 + and CD8 + T cell density data were available, and high tumour necrosis percentage showed a weak negative correlation with CD3 + T cell density in the centre of the tumour (beta = −0.099, P = 0.0013) independent of disease stage, MMR status, and other tumour and patient characteristics (Supplementary Table S3). Here, CD8A is linked to neoplasm.