TF and neoplasm: TF gene-targets also showed over-representation of several pro-survival intracellular signaling pathways that have been implicated in both tumor development and chemo-therapy resistance (decreased apoptosis; enhanced DNA repair; activation of the TGF-b, p38 MAPK stress-response and phosphoinositide 3-kinase (PI3K) pathways; activation of Wnt/-catenin signaling cascade and the crosstalk STAT signaling pathway) (see Supplementary Data 3).