Analyses of the genomic distribution of DMGs across the three AML-samples showed a large extent of overlap among 2 or three samples for the DM-genes with DMRs located at CpG islands (39% 30% and 24% for hyper-methylated DMGs in UD5, UD10 and AML2 respectively, Fig. 4a). Here, RUNX3 is linked to acute myeloid leukemia.