Thus, in order to generate a system that recapitulates microenvironment cues in SLO, we cultured MCL samples (Table 1), most of them from PB, in an optimized medium (PDLS medium) containing CD40L, IL-4 and BAFF, which are known to be fundamental to mimic interactions with T cells and stromal cells [16, 17]. The gene discussed is TNFSF13B; the disease is mantle cell lymphoma.