Thus, in order to generate a system that recapitulates microenvironment cues in SLO, we cultured MCL samples (Table 1), most of them from PB, in an optimized medium (PDLS medium) containing CD40L, IL-4 and BAFF, which are known to be fundamental to mimic interactions with T cells and stromal cells [16, 17]. This evidence concerns the gene IL4 and mantle cell lymphoma.