A reduction46 in GLB1L2 expression can lead to a decrease in the expression of a tumor-suppressor protein called Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 5, which is associated with malignant progression and unfavorable prognosis, indicating a tumor-suppressor function in breast, colon, bladder, hepatic cancers, and lung adenocarcinoma, etc. Jhun et al47 reported a reduced GLB1L2 expression in patients with prostate cancer. The gene discussed is ITIH5; the disease is Familial prostate cancer.