Upregulation of BCL2L14 was demonstrated in human osteosarcoma cells exposed to either bilirubin or lithocholic acid, which were shown to have deleterious consequences on osteoblasts, while ursodeoxycholic acid attenuated this effect, suggesting that BCL-G might be involved in osteoporosis in patients with liver diseases [80]. The gene discussed is BCL2L14; the disease is osteosarcoma.