Common prognostic factors have been highlighted in the literature: age, sex, nutritional status, performance status (PS), tumor size, lymph node involvement, distant metastasis, anatomical subsite (Siewert classification), surgery of the primary lesion, time to progression after first-line therapy, histology (SCC versus ADC) and human epidermal growth factor receptor-2 (HER2) status3. Here, ERBB2 is linked to neoplasm.