In MLL translocation-induced leukemias, constitutive recruitment of AEP to CpG-rich promoters by MLL fusions drives leukemic transformation, as an artificial fusion protein of the targeting module and the AHD domain, which lacks the YEATS domain, was able to transform HPCs (see MTM-AHD in Fig. 1a). The gene discussed is KMT2A; the disease is leukemia.