In contrast, the proliferation of normal human CD34 + cells was unaffected under the conditions where that of P31/FUJ cells was severely impaired (Fig. 8d, e), suggesting that the combined inhibition of MOZ/MORF KATs and DOT1L KMT selectively induces differentiation of CALM-AF10 leukemia cells. This evidence concerns the gene DOT1L and leukemia.