BTRC and hepatocellular carcinoma: In addition to β-TrCP-dependent ubiquitination, human YAP has also been shown to be ubiquitinated by the E3 ligase F-box and WD repeat domain-containing 7 (Fbxw7) in hepatocellular carcinoma cells, in which Fbxw7 levels correlate inversely with YAP protein levels43.