PLCG2 and non-small cell lung carcinoma: In addition, the changes of mitochondrial respiration in the PLCG2-overexpression (OE) H460 cells and the four cell lines with different levels of PLCG2 (H1299, A549, H460 and MRC-5) indicated that high level of PLCG2 in NSCLC cells contributes to the higher mitochondrial respiration, which suggested that PLCG2 can enhance mitochondrial function (Fig. 6A–H, I–L).