PLCG2 expression in a subpopulation of cells has been shown to confer the aggressiveness seen in SCLC and a subpopulation of cells with a high expression of PLCG2; this malignant phenotype is also represented by the enrichment of genes related to metastasis, chemotaxis, and stemness, including genes involved in WNT and BMT signaling and EMT [26]. The gene discussed is PLCG2; the disease is small cell lung carcinoma.