PRPF19 and colorectal carcinoma: As shown in Fig. 1C, higher expression of PRPF19 was detected in most of the 12 pairs of CRC tissues compared to the matched adjacent normal tissues, and PRPF19 was also upregulated in most of the CRC cell lines compared with that in normal colon epithelial cell line FHC (Supplementary Fig. 1C).