PRPF19 and colorectal carcinoma: Subsequently, transwell assays were conducted, and results indicated that upregulation of PRPF19 significantly promoted the migration and invasion capability of CRC cells in DLD1, HCT116, and HCT15 cells, whereas downregulation of PRPF19 caused the opposite effect (Fig. 2B, C, Supplementary Fig. 3B).