KLF4 inhibited colorectal cancer cell proliferation through upregulating p21 and NDRG2 (a molecule downstream of Myc), and downregulating cyclinD1 (the key molecule of cell cycle G1/S extension), GINS complex subunit 4 (GINS4), and IFITM3 (a tumor metastasis-associated molecule) [80, 82, 83]. The gene discussed is KLF4; the disease is colorectal cancer.