KLF4 and lung carcinoma: In fact, KLF4 inhibited the growth, migration, invasion, metastasis and EMT of lung cancer cells through SIRT6/Snails/KLF4, KLF4/Plac8, Numblike-KLF4, KLF4-MMP2 and c-Jun-NH2-terminal kinase signaling pathway [55–59].