In fact, KLF4 inhibited the growth, migration, invasion, metastasis and EMT of lung cancer cells through SIRT6/Snails/KLF4, KLF4/Plac8, Numblike-KLF4, KLF4-MMP2 and c-Jun-NH2-terminal kinase signaling pathway [55–59]. The gene discussed is KLF4; the disease is lung cancer.