High levels of CatB can promote pyroptosis by activating NLRP3 inflammasome in cardiomyocytes of coxsackievirus B3-induced viral myocarditis mice and streptozotocin-induced diabetic cardiomyopathy mice, and in endothelial cells of a mouse model of Kawasaki disease induced by Candida albicans cell wall extracts [72]. This evidence concerns the gene TYRP1 and Kawasaki disease.