Cytosolic CatB cleavage of BID and release of cytochrome C from the mitochondria could induce caspase-dependent apoptosis, which is a common mechanism by which CatB induces cell death in neurological disorders, such as retinitis pigmentosa, (focal) cerebral ischemia, TBI, lysosomal storage disorders, and AD [59, 61–64]. This evidence concerns the gene TYRP1 and Alzheimer disease.