Numerous researches have reported that lysosomal permeabilization enables the release of CatB into the cytoplasm in response to pathogenic stimuli through in vitro experiments and animal models of disease, including neurons from rats with cerebral ischemia induced by permanent middle cerebral artery occlusion and in vitro oxygen and glucose deprivation model, microglia and neurons treated with Aβ and from AD mice models, dopamine neurons treated with MPTP, cortex and hippocampus neurons from TBI mouse model, etc. [55–59]. This evidence concerns the gene TYRP1 and Cerebral ischemia.