Central members of the cytochrome system including CYTB and ND5 as well as mitochondrial ribosome components (MRPL) and central metabolic enzymes such as Aldehyde dehydrogenase (ALDH2) and L-2-Hydroxyglutarate dehydrogenase (L2HGDH) were increased in COVID-19 compared to normal human plasma and/or ICU-ARDS patients. Here, MT-CYB is linked to COVID-19.