Mitochondrial proteins such as ATP5A1, CYB561D1, several CYP accessions, L2HGDH, two MRP, MRPL37, NDUFS1 and others showed increased observation frequency across COVID-19 and ICU-ARDS versus NHP individually by the Chi Square test (χ2 ≥ 10, p ≤ 0.01) and as a group by one way ANOVA (p ≤ 0.003) (Table 3). This evidence concerns the gene CYB561D1 and acute respiratory distress syndrome.