MT-ND1 and COVID-19: Four independent lines of evidence including the PCR against the oxidase component ND1, the increased observation frequency of mitochondrial proteins in plasma by LC–ESI–MS/MS, the previously established structural and functional interactions between the increased proteins and the presence of a cytochrome-like ECL activity in COVID-19 plasma were all consistent with the loss of mitochondria and cytochrome components from cells in severe SARS-CoV-2 infection.