Chi Square analysis of corrected observation frequency indicated that cytochrome complex members including CYB, CYTB, CYP, CYBR, MT-COX, NDUF, MT-ND5 and other structurally or functionally related proteins were significantly elevated (χ2 ≥ 21, DF = 1, p ≤ 0.0001) in COVID-19 plasma (Table 4). The gene discussed is PPIG; the disease is COVID-19.