The increased presence of the cytochrome oxidase MT-COX2, cytochromes such as CYB, CYTB, or CYP or associated factors in the plasma of ARDS and COVID-19 patients as discovered by plasma proteomics was consistent with the measurements of increased cytochrome-like activity in the plasma of patients with respiratory distress [29–32]. The gene discussed is PPIG; the disease is acute respiratory distress syndrome.