For site 2 (D389-G390 of CaMKIIβ), proteolytic processing of CaMKIIβ and CaMKIIα at this site occurs in both sham-operated and ischemic stroke mouse brains (Fig. 7), indicating that it is a proteolytic processing event occurring in both physiological and pathological conditions. The gene discussed is CAMK2A; the disease is ischemic stroke.