Since ΔCaMKII-short was detectable in the brain cortex of wild-type mice but not in CaMKIIα KO mice subjected to ischemic stroke treatment (Fig. 7C, right panel), CaMKII-short in wild-type ischemic stroke mouse brains were likely mainly derived from cleavage of CaMKIIα at site 1 by calpains. This evidence concerns the gene CAMK2A and ischemic stroke.