As ischemic stroke induces CaMKIIα in the mouse brain to undergo autophosphorylation at Thr-286 in the autoinhibitory/CaM binding motif (26), we reasoned that CaMKIIβ was also autophosphorylated at the homologous site (Thr-287) in excitotoxic neurons in mouse brains subjected to ischemic stroke treatment. This evidence concerns the gene CAMK2B and ischemic stroke.