CAPN1 and ischemic stroke: Akin to the fragments generated by calpain-1 cleavage of pT286-rCaMKIIα in vitro, N-terminal fragments of CaMKIIα with molecular masses similar to ΔCaMKIIα-short (∼31 kDa) and ΔCaMKIIα-long (∼36 kDa) were detectable in brain cortex of mice subjected to ischemic stroke treatment (Fig. 7C, left panel).