CAMK2A and ischemic stroke: Upon autophosphorylation at Thr-286 induced in vivo by ischemic stroke and in vitro by incubation with Mg2+-ATP and CaM, site 1 of CaMKIIα was cleaved by calpains to generate ΔCaMKIIα-short consisting of just the intact kinase domain and a remnant segment of the autoinhibitory/CaM-binding motif.