Using the mouse model of cardiac arrest and pulmonary resuscitation (CA/CPR) that causes excitotoxic neuronal loss, CA/CPR induced significant brain damage and a significant increase in autophosphorylation at Thr-286 and the homologous threonine of CaMKII and other isoforms in synaptosome membrane fractions (25). This evidence concerns the gene CAMK2G and cardiac arrest.