In agreement with our TAILS findings in excitotoxic neurons, C-terminal truncated CRMP2 fragments of ∼57 kDa were detectable at 1 to 24 h after ischemic stroke induction (Fig. 3F), confirming cleavage of CRMP2 to form stable fragments in vivo after ischemia stroke. The gene discussed is DPYSL2; the disease is ischemic stroke.