Using APPswe/PS1dE9 (APP/PS1) rats expressing human amylin specifically in the pancreas (murine amylin is nonamyloidogenic), chronic exposure to circulating amyloid-forming amylin was found to promote cerebrovascular and parenchymal amylin-Aβ deposition (12, 13), consistent with findings in human AD brains (9, 10, 11, 12, 13). Here, IAPP is linked to Alzheimer disease.