TRH and Anxiety: (iv) The selectivity of circuit components suggests that behavioral outputs, if any, could include reward, reactivity to adverse stimuli through fear and anxiety,46, 47, 48 and circadian synchronization of TRH with synaptic output (e.g., for motivational aspects including sexual behavior)49, 50, 51 through the recruitment of the LHb and the septal complex, as well as other Onecut3− structures including the cortical amygdala complex.52