DLBCL patients with a higher-risk IPI show a significantly higher surface-TREM2 level on M-MDSCs (Fig. 2B) and a significantly lower absolute count of CD8+ T cells in PB (Fig. 4C), implicating that high-risk DLBCL causes devastating reduction in the number of circulating CD8+ T cells by TREM2-associated signaling. This evidence concerns the gene CD8A and diffuse large B-cell lymphoma.