Given that the level of surface TREM2 on M-MDSCs was positively correlated to intracellular ARG1 and negatively associated with the absolute count of PB CD8+ T cells in DLBCL patients, we hypothesize that TREM2 may regulate the expression of ARG1 to impair the proliferation of CD8+ T cells. The gene discussed is CD8A; the disease is diffuse large B-cell lymphoma.