IGFBP2 and medulloblastoma: To determine whether IGFBP2 is over-expressed in medulloblastoma we re-analyzed microarray data from the [6] medulloblastoma patient dataset and found that the RNA levels of IGFBP2 are elevated across all MB subgroups (Fig. 1e, IGFBP2 expression was similar across SHH and non-SHH MB cell lines (Additional file 1: Fig. S1b).