We also carried out western blotting of medulloblastoma and adjacent non-tumor tissue from NeuroD2: Smo/A1 mice, and we observed higher levels of IGFBP2 in tumor tissue (Fig. 2b); its levels were very low by comparison in a mouse model for Myc-amplified non-SHH medulloblastoma (Additional file 1: Fig. S2c). Here, MYC is linked to medulloblastoma.