As described below, our studies in primary mouse SHH medulloblastoma cells and human SHH MB cell lines reveal an essential role for MB cell-derived IGFBP2 in cell proliferation and migration, and we identify STAT3 as a downstream effector of IGFBP2 in regulation of epithelial to mesenchymal transition (EMT) and cell migration, critical steps in metastasis, suggesting a potential for targeting the IGFBP2-STAT3 axis for preventing tumor cell growth and metastasis. This evidence concerns the gene IGFBP2 and medulloblastoma.