These results are mirrored in our platelet transcriptomics, where SLE subjects showed upregulation of interferon related genes (IFITM1, IFI27, RSAD2, IFIT3, LGALS3BP) and the most enriched for pathways amongst the differentially expressed genes were interferon gamma response and interferon alpha response. This evidence concerns the gene RSAD2 and systemic lupus erythematosus.